| Name | Spouse | Marriage date | Marriage location |
|---|
| Debbie Holbrook | | | |
| Della Holbrook | | | |
| Delpha Holbrook | | | |
| Delphia Holbrook | | | |
| Dessel Lou Holbrook | Walters, Sebe | Private | |
| Detroit Holbrook | Lettie | | |
| Dewey Douglas Holbrook | | | |
| Dewey Kel Holbrook | Burton, Nora | Private | |
| Dinie Holbrook | | | |
| Dora M. Holbrook | McLaughlin, Ray | Private | |
| Edward G. Holbrook | Mary | | |
| Edward Holbrook | | | |
| Edy Holbrook | Tolben, Mary | October 07, 1756 | Goochland Co., Virginia |
| Edy Holbrook | | | |
| Effie Ann Holbrook | Lykins, William Orvell | Private | |
| Elizabeth "Betsy" Holbrook | Passmore, James | | |
| Elizabeth Holbrook | Venables, Samuel | | |
| Elizabeth Holbrook | | | |
| Elizabeth Holbrook | Earle, Samuel | January 13, 1754 | Sanford CO., Virginia |
| Elizabeth Holbrook | Skaggs, Moses | | |
| Elizabeth Holbrook | | | |
| Elizabeth Holbrook | Shepherd, John C. | December 16, 1870 | Floyd Co., Kentucky |
| Elizabeth Holbrook | | | |
| Elizabeth Holbrook | | | |
| Elizabeth Holbrook | | | |
| Elyia Holbrook | | | |
| Emanuel Washington Holbrook | | | |
| Emelia " Millie " Holbrook | Skaggs, Jeremiah | July 18, 1821 | Floyd Co., Kentucky |
| Emily Evangeline "Milly" Holbrook | | | |
| Ennis Holbrook | | | |
| Ernest C. Holbrook | | | |
| Eugean Holbrook | | | |
| Eva Denise Holbrook | | | |
| Eva Holbrook | Butler, Merrill R. | Private | |
| Eva Jane Holbrook | Puckett, Harrison | May 05, 1897 | Floyd Co., Kentucky |
| Evaline Holbrook | Shepherd, Wesley Land | December 23, 1868 | Goodloe, Floyd Co., Kentucky |
| Ezekiel Holbrook | Adams, Elizabeth | | |
| Fannie A. Holbrook | Smith, David | August 11, 1852 | |
| Filmore Hardin Holbrook | | | |
| Floyd Handy Holbrook | Jane | | |
| Frances Holbrook | | | |
| Frances Holbrook | Lyons, Jesse | Abt. 1810 | |
| Frances Holbrook | Holbrook, William " Hargis " | January 05, 1854 | Johnson Co., Kentucky |
| Frank J. Holbrook | | | |
| Frank M. Holbrook | | | |
| Fred D. Holbrook | | | |
| Gale Holbrook | Fields, Barbara Ann | Private | |
| George D. Holbrook | | | |
| George Holbrook | | | |
| George Washington Holbrook | Music, Rachel | | |
