| Name | Birth date | Birth location | Death date | Death location |
|---|
| Debbie Holbrook | Private | | | |
| Della Holbrook | WFT Est. 1880-1907 | | Unknown | |
| Delpha Holbrook | Private | | | |
| Delphia Holbrook | 1851 | Wilkes Co., North Carolina | Unknown | |
| Dessel Lou Holbrook | December 30, 1914 | Kentucky | April 24, 1968 | Magoffin, Co., Kentucky |
| Detroit Holbrook | May 04, 1850 | Lawrence Co., Kentucky | October 16, 1853 | Lawrence Co., Kentucky |
| Dewey Douglas Holbrook | Private | | | |
| Dewey Kel Holbrook | March 26, 1927 | | February 25, 1973 | Johnson Fork, Magoffin Co., Kentucky |
| Dinie Holbrook | Private | | | |
| Dora M. Holbrook | Private | | | |
| Edward G. Holbrook | February 1836 | Kentucky | Unknown | |
| Edward Holbrook | | | Unknown | |
| Edy Holbrook | Abt. 1732 | Goochland Co., Virginia | Unknown | |
| Edy Holbrook | Aft. 1758 | | Unknown | |
| Effie Ann Holbrook | November 04, 1919 | Dale, Magoffin Co., Kentucky | May 10, 1959 | Hager, Magoffin Co., Kentucky |
| Elizabeth "Betsy" Holbrook | Bet. 1801 - 1810 | Surry Co., North Carolina | February 05, 1838 | |
| Elizabeth Holbrook | Abt. 1693 | | Unknown | |
| Elizabeth Holbrook | 1693 | | Unknown | |
| Elizabeth Holbrook | Abt. 1733 | | Unknown | |
| Elizabeth Holbrook | June 16, 1810 | North Carolina | May 19, 1890 | Lawrence Co., Kentucky |
| Elizabeth Holbrook | 1838 | | Unknown | |
| Elizabeth Holbrook | April 18, 1856 | Middle Creek, Floyd Co., Kentucky | Bet. 1895 - 1951 | |
| Elizabeth Holbrook | WFT Est. 1787-1816 | | Unknown | |
| Elizabeth Holbrook | Abt. 1874 | | Unknown | |
| Elizabeth Holbrook | 1875 | McDowell Co., West Virginia | Unknown | |
| Elyia Holbrook | WFT Est. 1835-1864 | | Unknown | |
| Emanuel Washington Holbrook | January 27, 1846 | Macon Co., North Carolina | Abt. 1857 | Macon Co., North Carolina |
| Emelia " Millie " Holbrook | Abt. 1802 | North Carolina | September 04, 1875 | |
| Emily Evangeline "Milly" Holbrook | December 23, 1841 | Lawrence Co., Kentucky | Unknown | |
| Ennis Holbrook | 1872 | North Carolina | Unknown | |
| Ernest C. Holbrook | Private | | | |
| Eugean Holbrook | Private | | | |
| Eva Denise Holbrook | Private | | | |
| Eva Holbrook | Private | | | |
| Eva Jane Holbrook | January 1880 | Floyd Co., Kentucky | Unknown | |
| Evaline Holbrook | July 18, 1852 | Goodloe, Floyd Co., Kentucky | May 01, 1907 | Brush Hill, McIntosh Co., Oklahoma |
| Ezekiel Holbrook | 1800 | Green Street Mountain, Wilkes Co., North Carolina | Unknown | Wilkes Co., North Carolina |
| Fannie A. Holbrook | | | Unknown | |
| Filmore Hardin Holbrook | October 22, 1856 | Macon Co., North Carolina | Abt. 1857 | Macon Co., North Carolina |
| Floyd Handy Holbrook | July 19, 1872 | | Unknown | |
| Frances Holbrook | WFT Est. 1787-1816 | | Unknown | |
| Frances Holbrook | 1791 | North Carolina | Aft. 1860 | Lawrence Co., Kentucky |
| Frances Holbrook | January 25, 1833 | | 1873 | |
| Frank J. Holbrook | 1873 | McDowell Co., West Virginia | Unknown | |
| Frank M. Holbrook | | | Unknown | |
| Fred D. Holbrook | Private | | | |
| Gale Holbrook | Private | | | |
| George D. Holbrook | Private | | | |
| George Holbrook | Abt. 1867 | | Unknown | |
| George Washington Holbrook | Abt. 1894 | | Unknown | |
