| Name | Birth date | Relationship with Kayanna Smith |
| Sarah | 1715 | 7th great-grandmother |
| Sarah | 1760 | Wife of the 5th great-granduncle |
| Sawtell, Richard | 1611 | 10th great-grandfather |
| Saxton, John | | Husband of the 3rd cousin 4 times removed |
| Sayre, Sarah Ann | 29 Sep 1843 | 2nd great-grandmother |
| Sayre, Stacy Lloyd | 27 Mar 1808 | 3rd great-grandfather |
| Schell, Elizabeth | 07 Sep 1634 | 8th great-grandmother |
| Schell, Hans | 1608 | 9th great-grandfather |
| Schlemer, Maria | 1660 | 8th great-grandmother |
| Schlemer, Wilhelm | 1640 | 9th great-grandfather |
| Schoelch, Maria Eva | 03 Feb 1677/78 | Wife of the 7th great-grandfather |
| Scott, Agnes | 1461 | 15th great-grandmother |
| Scott, Elizabeth | 1519 | 11th great-grandmother of the husband |
| Seaborn, Bridget | 1626 | Wife of the 9th great-grandfather |
| Seaborn, Bridgett | 1625 | Wife of the 9th great-grandfather |
| Seale, Robert | | Husband of the 9th great-grandmother |
| Shipley, Rosanna Fish | 26 Oct 1827 | 3rd great-grandmother |
| Shircliffe, Anne | 1635 | 9th great-grandmother |
| Shircliffe, John | 1457 | 15th great-grandfather |
| Shircliffe, John | 1618 | 10th great-grandfather |
| Shircliffe, John, Jr. | 1494 | 14th great-grandfather |
| Shircliffe, Richard | 1520 | 13th great-grandfather |
| Shircliffe, Robert | 1548 | 12th great-grandfather |
| Shircliffe, Thomas | 1573 | 11th great-grandfather |
| Shircliffe, William | 1410 | 16th great-grandfather |
| Short, Elizabeth | 01 May 1638 | 9th great-grandmother |
| Simpson, Alexander | 11 May 1837 | 2nd cousin 3 times removed of the husband |
| Simpson, Amanda | 14 Nov 1823 | 2nd cousin 3 times removed of the husband |
| Simpson, Anne | 1838 | 2nd cousin 3 times removed of the husband |
| Simpson, Barbara | | 2nd cousin 3 times removed of the husband |
| Simpson, Benjamin Franklin | | 2nd cousin 3 times removed of the husband |
| Simpson, Charles | 28 May 1842 | 2nd cousin 3 times removed of the husband |
| Simpson, Claricy | 04 Feb 1845 | 2nd cousin 3 times removed of the husband |
| Simpson, Cynthia | 08 May 1830 | 2nd cousin 3 times removed of the husband |
| Simpson, Frances | 20 Aug 1834 | 2nd cousin 3 times removed of the husband |
| Simpson, George | 1840 | 2nd cousin 3 times removed of the husband |
| Simpson, John | 1832 | 2nd cousin 3 times removed of the husband |
| Simpson, John H. | | 2nd cousin 3 times removed of the husband |
| Simpson, Mary | 1846 | 2nd cousin 3 times removed of the husband |
| Simpson, Robert | 14 Dec 1821 | 2nd cousin 3 times removed of the husband |
| Simpson, Samuel | 12 Apr 1828 | 2nd cousin 3 times removed of the husband |
| Simpson, Sarah Ann | 07 Apr 1832 | 2nd cousin 3 times removed of the husband |
| Simpson, Thomas | 1849 | 2nd cousin 3 times removed of the husband |
| Simpson, William Wyle | 22 Jun 1839 | 2nd cousin 3 times removed of the husband |
| Sippie | 31 Dec 1853 | 2nd cousin 3 times removed of the husband |
| Smith, Catherine Elizabeth | | Aunt |
| Smith, Conor | 21 Mar 2000 | Nephew |
| | | Half 5th cousin twice removed |
| Smith, Daniel Joseph | 13 Jan 1938 | Father |
| | | Ex-husband of the half 5th cousin |